Publications

Band G, Le QC, Clarke GM, Kivinen K, Hubbart C, Jeffreys AE, Rowlands K, Leffler EM, Jallow M, Conway DJ, Sisay-Joof F, d’Alessandro U, Toure OB, Thera MA, Konate S, Sissoko S, Mangano VD, Bougouma ED, Sirima SB, Amenga-Etego LN, Ghansah AK, Hodgson AVO, Wilson MD, Enimil A, Ansong D, Evans J, Ademola SA, Apinjoh TO, Ndila CM, Manjurano A, Drakeley C, Reyburn H, Nguyen HP, Nguyen TNQ, Thai CQ, Hien TT, Teo YY, Manning L, Laman M, Michon P, Karunajeewa H, Siba P, Allen S, Allen, A, Bahlo M, Davis TME, Cornelius V, Shelton J, Spencer CCA, Busby GBJ, Kerasidou A, Drury E, Stalker J, Dilthey A, Mentzer AJ, McVean G, Bojang KA, Doumbo O, Modiano D, Koram KA, Agbenyega T, Amodu OK, Achidi E, Williams TN, Marsh K, Riley EM, Molyneux M, Taylor T, Dunstan SJ, Farrar J, Mueller I, Rockett KA, and DP Kwiatkowski. Insights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia, and Oceania. Nature Communications 16 December 2019 10, 5732 [Nature Communications[bioRxiv]

Busby GBJ, Christ R, Band G, Leffler EM, Le QS, MalariaGEN, Rockett KA, Kwiatkowski DP and CCA Spencer. Inferring adaptive gene flow in recent African history. biorXiv 2017 [bioRxiv]

Leffler EM. Evolutionary insights from wild vervet genomes. Nature Genetics 29 November 2017 49, 1671–1672. [Nature Genetics] [PMC]

Leffler EM, Band G, Busby GBJ, Kivinen K, Le QS, Clarke GM, Bojang KA, Conway DJ, Jallow M, Sisay-Joof F, Bougouma EC, Mangano VD, Modiano D, Sirima SB, Achidi E, Apinjoh TO, Marsh K, Ndila CM, Peshu N, Williams TN, Drakeley C, Manjurano A, Reyburn H, Riley E, Kachala D, Molyneux M, Nyirongo V, Taylor T, Thornton N, Tilley L, Grimsley S, Drury E, Stalker J, Cornelius V, Hubbart C, Jeffreys AE, Rowlands K, Rockett KA, Spencer CCA, Kwiatkowski DP and Malaria Genomic Epidemiology Network. Resistance to malaria through structural variation of red blood cell invasion receptors. Science 16 June 2017 356(6343): eaam6393. [Science] [PMC] [bioRxiv]

Singhal S*, Leffler EM*, Sannareddy K, Turner I, Venn O, Hooper DM, Strand AI, Li Q, Raney B, Balakrishnan CN, Griffith SC, McVean G, and M Przeworski. Stable recombination hotspots in birds. Science 20 Nov 2015 350:928-32 [Science] [PMC] [bioRxiv]

Malaria Genomic Epidemiology Network. A novel locus of resistance to severe malaria in a region of ancient balancing selection. Nature 8 October 2015 526:253-7 [Nature] [PMC]

Leffler EM*, Gao Z*, Pfeifer S*, Segurel L*, Auton A, Venn O, Bowden R, Bontrop R, Wall JD, Sella G, Donnelly P, McVean G+, and M Przeworski+. Multiple instances of ancient balancing selection shared between humans and chimpanzees. Science 29 March 2013 339:1578-1582 [Science] [PMC]

Leffler EM, Bullaughey K*, Matute DR*, Meyer WK*, Segurel L*, Venkat A*, Andolfatto P, and M Przeworski. Revisiting an Old Riddle: What Determines Genetic Diversity Levels within Species? PLoS Biology Sept 2012 10(9):e1001388 [PLoS Biology]

Auton A*, Fledel-Alon A*, Pfeifer S*, Venn O*, Ségurel L, Street T, Leffler EM, Bowden R, Ineas I, Broxholme J, Humburg J, Iqbal Z, Lunter G, Maller J, Hernandez RD, Melton SC, Venkat A, Nobrega M, Bontrop R, Donnelly P+, Przeworski M+, and G McVean+. A fine-scale chimpanzee genetic map from population resequencing data. Science 13 April 2012 336:193-198 [Science] [PMC]

Segurel L, Leffler EM, and M Przeworski. The case of the fickle fingers: How PRDM9 specifies meiotic recombination hotspots in humans. PLoS Biology Dec 2011 9(12):e1001211 [PLoS Biology]

Fledel-Alon A*, Leffler EM*, Guan Y, Stephens M, Coop G+ and M Przeworski+, 2011 Variation in human recombination rates and its genetic determinants. PLoS One June 2011 6(6):e20321 [PLoS One]